Upregulated CXCL10 gene Expression in SARS-CoV-2 Infected people

Abstract

Interferon and interferon-induced genes play a crucial role in early-stage post-infection virus defense. C-X-C10, also known as interferon gamma-induced protein 10 or small-inducible cytokine B10, is encoded by the CXCL10 gene and is essential for T-helper cell recruitment. The purpose of this study was to assess the gene expression of CXCL10 in SARS-CoV-2-positive and -negative individuals using qPCR. The results demonstrated a 35-fold increase in CXCL10 expression in SARS-CoV-2-positive individuals vs to negative samples. In conclusion, the elevated gene expression of CXCL10 in SARS-CoV-2 patients is a signal for the immune system to respond to the invading virus and may be taken into account in the design of future vaccines.