A study of IL-35 and IL-17 Levels for People with Periodontal Disease

Abstract

This research aims to evaluate the functions of IL-17 and IL-35 indicators in periodontal disease. This investigation involved forty-five patients with periodontal disease and forty-five healthy individuals as a control group. from November 2023 until April 2024. All indicators were quantified using enzyme-linked immunosorbent assay (ELISA). The findings of the present investigation indicated. The findings revealed that the majority of patients were male (66.7%) and smokers (57.8%), with a predominant age range of 51 to 60 years (35.6%). He also observed elevated levels of IL-17 and IL-35 in patients comparing to the healthy control group (p<0.05). The ROC curve analysis indicated that IL-17 exhibited superior sensitivity, specificity, odds ratio, and relative risk compared to IL-35, all demonstrating significant differences (p<0.05). A positive connection existed between IL-17 and IL-35 (r=0.249), although it was not statistically significant (p>0.05). This study indicated that IL-17 is more crucial for identifying periodontal disease due to its superior sensitivity and specificity in comparison to IL-35.