Synthesis, Characterization and Microbiological Activities of a new Schiff Base Derived from Hydralazine Hydrochloride

Abstract

The work describes the synthesis, characterization, and assessment of the biological activity of two novel Schiff bases, PHMP and BPHMP. The condensation process between hydralazine hydrochloride and terephthalaldehyde, facilitated by p-toluenesulfonic acid as a catalyst, resulted in their production. The compounds were studied by spectroscopic techniques, including FTIR, proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), and mass spectrometry. The antibacterial and antifungal efficacy of the Schiff base compounds assessed against the bacteria S. aureus and E. coli, as well as the fungus C. albicans and A. niger, yielded varying outcomes in comparison to hydralazine hydrochloride as the standard drugs.