Adenosine Deaminase Activity a Biomarker for Rheumatoid Arthritis: Review

Abstract

Rheumatoid arthritis (RA) is an autoimmune, chronic, inflammatory and symmetric disease. In order to avoid joint destruction and reduce it, it requires knowledge of the vital components causing the disease, so it is essential to start early in diagnosis and suitable treatment. Although clinical symptoms and the results of radiography help to identify and measure the activity of RA disease, biochemical markers also act as indicators of early diagnosis of the disease activity. So, therefore, the diagnosis of the disease at an early stage must choose a strong relationship with the disease. One of the vital signs related to rheumatoid arthritis is adenosine deaminase (ADA). The destruction of adenosine by the adenosine pathway facilitates a series of infections, such as rheumatoid arthritis. So there are many questions that come to our minds, namely:. Can the level of adenosine activity (ADA) be a biomarker of the distinction between RA patients and controls? Can adenosine deaminase be a biomarker indicator for diagnosing rheumatoid arthritis at the stage early pre-radiographically? And, does adenosine deaminase activity give an indication of disease activity?  In this review article, we're going to show the studies that pointed to those questions.