Upregulated CXCL10 gene Expression in SARS-CoV-2 Infected people

المؤلفون

  • Ruaa Salim Hameed Department of Biology, College of Science, University of Basrah, Basra, Iraq. مؤلف
  • Mohammed Hussein Waheed PCR laboratory, Public Health Department, Health Directorate, Basra, Iraq. مؤلف
  • Zeenah Weheed Atwan Microbiology Department, College of Medicine, University of Basrah, Basra, Iraq. مؤلف

الكلمات المفتاحية:

SARS-CoV-2, CXCL10, Gene expression, Real-Time PCR, COVID-19 vaccine.

الملخص

Interferon and interferon-induced genes play a crucial role in early-stage post-infection virus defense. C-X-C10, also known as interferon gamma-induced protein 10 or small-inducible cytokine B10, is encoded by the CXCL10 gene and is essential for T-helper cell recruitment. The purpose of this study was to assess the gene expression of CXCL10 in SARS-CoV-2-positive and -negative individuals using qPCR. The results demonstrated a 35-fold increase in CXCL10 expression in SARS-CoV-2-positive individuals vs to negative samples. In conclusion, the elevated gene expression of CXCL10 in SARS-CoV-2 patients is a signal for the immune system to respond to the invading virus and may be taken into account in the design of future vaccines.

 

التنزيلات

تنزيل البيانات ليس متاحًا بعد.

التنزيلات

منشور

2022-08-31

إصدار

مجلد 40 عدد 2 (2022)

القسم

Biology

الرخصة

Creative Commons License

هذا العمل مرخص بموجب Creative Commons Attribution-NonCommercial 4.0 International License.